Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
Identifieur interne : 001F21 ( Main/Exploration ); précédent : 001F20; suivant : 001F22Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
Auteurs : T. D. L. Steeves [Canada] ; J. Miyasaki [Canada] ; M. Zurowski [Canada] ; A. E. Lang [Canada] ; G. Pellecchia [Canada] ; T. Van Eimeren [Canada] ; P. Rusjan [Canada] ; S. Houle [Canada] ; A. P. Strafella [Canada]Source :
- Brain [ 0006-8950 ] ; 2009-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Carbon Radioisotopes, Case-Control Studies, Corpus Striatum (diagnostic imaging), Corpus Striatum (secretion), Dopamine, Dopamine (analysis), Dopamine (secretion), Dopamine Antagonists (therapeutic use), Emission tomography, Female, Functional imaging, Gambling (psychology), Human, Humans, Impulse control disorder, Male, Middle Aged, Nervous system diseases, Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson disease, Pathological gambling, Positron emission tomography, Positron-Emission Tomography, Protein Binding, Raclopride, Raclopride (therapeutic use), Release.
- MESH :
- chemical , analysis : Dopamine.
- chemical , secretion : Dopamine.
- chemical , therapeutic use : Dopamine Antagonists, Raclopride.
- chemical : Carbon Radioisotopes.
- diagnostic imaging : Corpus Striatum, Parkinson Disease.
- physiopathology : Parkinson Disease.
- psychology : Gambling, Parkinson Disease.
- secretion : Corpus Striatum.
- Aged, Analysis of Variance, Case-Control Studies, Female, Humans, Male, Middle Aged, Positron-Emission Tomography, Protein Binding.
Abstract
Pathological gambling is an impulse control disorder reported in association with dopamine agonists used to treat Parkinson's disease. Although impulse control disorders are conceptualized as lying within the spectrum of addictions, little neurobiological evidence exists to support this belief. Functional imaging studies have consistently demonstrated abnormalities of dopaminergic function in patients with drug addictions, but to date no study has specifically evaluated dopaminergic function in Parkinson's disease patients with impulse control disorders. We describe results of a [11C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson's disease patients, with and without pathological gambling, following dopamine agonists. Patients with pathological gambling demonstrated greater decreases in binding potential in the ventral striatum during gambling (13.9%) than control patients (8.1%), likely reflecting greater dopaminergic release. Ventral striatal bindings at baseline during control task were also lower in patients with pathological gambling. Although prior imaging studies suggest that abnormality in dopaminergic binding and dopamine release may be markers of vulnerability to addiction, this study presents the first evidence of these phenomena in pathological gambling. The emergence of pathological gambling in a number of Parkinson's disease patients may provide a model into the pathophysiology of this disorder.
Url:
- https://api-v5.istex.fr/document/01775AC302FFF4C21CE17E62D41BE1C63933DB04/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479148
DOI: 10.1093/brain/awp054
Affiliations:
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Le document en format XML
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Although impulse control disorders are conceptualized as lying within the spectrum of addictions, little neurobiological evidence exists to support this belief. Functional imaging studies have consistently demonstrated abnormalities of dopaminergic function in patients with drug addictions, but to date no study has specifically evaluated dopaminergic function in Parkinson's disease patients with impulse control disorders. We describe results of a [11C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson's disease patients, with and without pathological gambling, following dopamine agonists. Patients with pathological gambling demonstrated greater decreases in binding potential in the ventral striatum during gambling (13.9%) than control patients (8.1%), likely reflecting greater dopaminergic release. Ventral striatal bindings at baseline during control task were also lower in patients with pathological gambling. Although prior imaging studies suggest that abnormality in dopaminergic binding and dopamine release may be markers of vulnerability to addiction, this study presents the first evidence of these phenomena in pathological gambling. The emergence of pathological gambling in a number of Parkinson's disease patients may provide a model into the pathophysiology of this disorder.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Steeves, T D L" sort="Steeves, T D L" uniqKey="Steeves T" first="T. D. L." last="Steeves">T. D. L. Steeves</name></noRegion><name sortKey="Houle, S" sort="Houle, S" uniqKey="Houle S" first="S." last="Houle">S. Houle</name><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><name sortKey="Miyasaki, J" sort="Miyasaki, J" uniqKey="Miyasaki J" first="J." last="Miyasaki">J. Miyasaki</name><name sortKey="Pellecchia, G" sort="Pellecchia, G" uniqKey="Pellecchia G" first="G." last="Pellecchia">G. Pellecchia</name><name sortKey="Rusjan, P" sort="Rusjan, P" uniqKey="Rusjan P" first="P." last="Rusjan">P. Rusjan</name><name sortKey="Steeves, T D L" sort="Steeves, T D L" uniqKey="Steeves T" first="T. D. L." last="Steeves">T. D. L. Steeves</name><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name><name sortKey="Van Eimeren, T" sort="Van Eimeren, T" uniqKey="Van Eimeren T" first="T." last="Van Eimeren">T. Van Eimeren</name><name sortKey="Zurowski, M" sort="Zurowski, M" uniqKey="Zurowski M" first="M." last="Zurowski">M. Zurowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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